Signatures and Specificity of Tissue-Resident Lymphocytes Identified in Human Renal Peritumor and Tumor Tissue.

ABSTRACT:

Background

Tissue-resident memory T (T_RM) cells are known to be important for the first line of defense in mucosa-associated tissues. However, the composition, localization, effector function, and specificity of T_RM cells in the human kidney and their relevance for renal pathology have not been investigated.

Methods

Lymphocytes derived from blood, renal peritumor samples, and tumor samples were phenotypically and functionally assessed by applying flow cytometry and highly advanced histology (multi-epitope ligand cartography) methods.

Results

CD69⁺CD103⁺CD8⁺ T_RM cells in kidneys display an inflammatory profile reflected by enhanced IL-2, IL-17, and TNFα production, and their frequencies correlate

SUBMITTER: Dornieden T 

PROVIDER: S-EPMC8729844 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature