Proteins Associated with Risk of Kidney Function Decline in the General Population.

ABSTRACT:

Background

Proteomic profiling may allow identification of plasma proteins that associate with subsequent changesin kidney function, elucidating biologic processes underlying the development and progression of CKD.

Methods

We quantified the association between 4877 plasma proteins and a composite outcome of ESKD or decline in eGFR by ≥50% among 9406 participants in the Atherosclerosis Risk in Communities (ARIC) Study (visit 3; mean age, 60 years) who were followed for a median of 14.4 years. We performed separate analyses for these proteins in a subset of 4378 participants (visit 5), who were followed at a later time point, for a median of 4.4 years. For validation, we evaluated proteins with significant associations (false discovery rate <5%) in both time periods in 3249 pa

SUBMITTER: Grams ME 

PROVIDER: S-EPMC8729856 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature