Evaluation of the safety profile of the vaccine candidate Brucella melitensis 16MΔvjbR strain in goats.

ABSTRACT: Small ruminant brucellosis is caused by the Gram negative cocci-bacillus Brucella (B.) melitensis, the most virulent Brucella species for humans. In goats and sheep, middle to late-term gestation abortion, stillbirths and the delivery of weak infected offspring are the characteristic clinical signs of the disease. Vaccination with the currently available Rev. 1 vaccine is the best option to prevent and control the disease, although it is far from ideal. In this study, we investigate the safety of the B. melitensis 16MΔvjbR strain during a 15-month period beginning at vaccination of young goats, impregnation, delivery and lactation. Forty, 4 to 6 months old, healthy female crossbreed goats were randomly divided into four groups (n = 10) and immunized subcutaneously with a single vaccine dos

SUBMITTER: Castano-Zubieta MR 

PROVIDER: S-EPMC8730362 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature