Impact of procedural variability and study design quality on the efficacy of cell-based therapies for heart failure - a meta-analysis.

ABSTRACT:

Background

Cell-based therapy has long been considered a promising strategy for the treatment of heart failure (HF). However, its effectiveness in the clinical setting is now doubted. Because previous meta-analyses provided conflicting results, we sought to review all available data focusing on cell type and trial design.

Methods and findings

The electronic databases PubMed, Cochrane library, ClinicalTrials.gov, and EudraCT were searched for randomized controlled trials (RCTs) utilizing cell therapy for HF patients from January 1, 2000 to December 31, 2020. Forty-three RCTs with 2855 participants were identified. The quality of the reported study design was assessed by evaluating the risk-of-bias (ROB). Primary outcomes were defined as mortality rate and left ventricular eje

SUBMITTER: Xu Z 

PROVIDER: S-EPMC8730409 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature