Delta opioid receptor regulation of calcitonin gene-related peptide dynamics in the trigeminal complex.

ABSTRACT:

Abstract

Migraine is highly prevalent and is the sixth leading cause worldwide for years lost to disability. Therapeutic options specifically targeting migraine are limited, and delta opioid receptor (DOP) agonists were recently identified as a promising pharmacotherapy. The mechanisms by which DOPs regulate migraine are currently unclear. Calcitonin gene-related peptide (CGRP) has been identified as an endogenous migraine trigger and plays a critical role in migraine initiation and susceptibility. The aim of this study was to determine the behavioral effects of DOP agonists on the development of chronic migraine-associated pain and to investigate DOP coexpression with CGRP and CGRP receptor (CGRPR) in the trigeminal system. Chronic migraine-associated pain was induced in mice thro

SUBMITTER: Moye LS 

PROVIDER: S-EPMC8730473 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature