Impaired T-Lymphocyte Responses During Childhood Staphylococcus aureus Infection.

ABSTRACT:

Background

Staphylococcus aureus infections are common throughout the lifespan, with recurrent infections occurring in nearly half of infected children. There is no licensed vaccine, underscoring the need to better understand how S. aureus evades protective immunity. Despite much study, the relative contributions of antibodies and T cells to protection against S. aureus infections in humans are not fully understood.

Methods

We prospectively quantified S. aureus-specific antibody levels by ELISA and T-cell responses by ELISpot in S. aureus-infected and healthy children.

Results

S. aureus-specific antibody levels and T-cell responses increased with age in healthy children, suggesting a coordinated development of anti-staphylococcal immunity. Antibody levels against leuk

SUBMITTER: Li Z 

PROVIDER: S-EPMC8730493 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature