Secretor Status Strongly Influences the Incidence of Symptomatic Norovirus Infection in a Genotype-Dependent Manner in a Nicaraguan Birth Cohort.

ABSTRACT:

Background

The role of histo-blood group on the burden and severity of norovirus gastroenteritis in young infants has not been well documented.

Methods

Norovirus gastroenteritis was assessed in 443 Nicaraguan children followed from birth until 3 years of age. Stool samples were tested for norovirus by reverse-transcription quantitative polymerase chain reaction (RT-qPCR), and histo-blood group antigens (HBGAs) were determined by phenotyping of saliva and blood. Hazard ratios and predictors of norovirus acute gastroenteritis (AGE) outcome stratified by HBGA were estimated using Cox proportional hazards models.

Results

Of 1353 AGE episodes experienced by children, 229 (17%) tested positive for norovirus with an overall incidence of 21.9/100 child-years. Secretor childre

SUBMITTER: Reyes Y 

PROVIDER: S-EPMC8730499 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature