Low hemoglobin levels are independently associated with neonatal acute kidney injury: a report from the AWAKEN Study Group.

ABSTRACT:

Background

Studies in adults showed a relationship between low hemoglobin (Hb) and acute kidney injury (AKI). We performed this study to evaluate this association in newborns.

Methods

We evaluated 1891 newborns from the Assessment of Worldwide AKI Epidemiology in Neonates (AWAKEN) database. We evaluated the associations for the entire cohort and 3 gestational age (GA) groups: <29, 29-<36, and ≥36 weeks' GA.

Results

Minimum Hb in the first postnatal week was significantly lower in neonates with AKI after the first postnatal week (late AKI). After controlling for multiple potential confounders, compared to neonates with a minimum Hb ≥17.0 g/dL, both those with minimum Hb ≤12.6 and 12.7-14.8 g/dL had an adjusted increased odds of late AKI (aOR 3.16, 95% CI 1.44-6.96, p =

SUBMITTER: Nada A 

PROVIDER: S-EPMC8730540 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature