Serum Analyte Profiles Associated With Crohn's Disease and Disease Location.

ABSTRACT:

Background

Crohn's disease (CD) can affect any segment of the digestive tract but is most often localized in the ileal, ileocolonic, and colorectal regions of the intestines. It is believed that the chronic inflammation in CD is a result of an imbalance between the epithelial barrier, the immune system, and the intestinal microbiota. The aim of the study was to identify circulating markers associated with CD and/or disease location in CD patients.

Methods

We tested 49 cytokines, chemokines, and growth factors in serum samples from 300 patients with CD and 300 controls. After quality control, analyte levels were tested for association with CD and disease location.

Results

We identified 13 analytes that were higher in CD patients relative to healthy controls and that re

SUBMITTER: Boucher G 

PROVIDER: S-EPMC8730700 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature