The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle.

ABSTRACT: Excitation-contraction coupling (ECC) is the process by which electrical excitation of muscle is converted into force generation. Depolarization of skeletal muscle resting potential contributes to failure of ECC in diseases such as periodic paralysis, intensive care unit acquired weakness and possibly fatigue of muscle during vigorous exercise. When extracellular K+ is raised to depolarize the resting potential, failure of ECC occurs suddenly, over a narrow range of resting potentials. Simultaneous imaging of Ca2+ transients and recording of action potentials (APs) demonstrated failure to generate Ca2+ transients when APs peaked at potentials more negative than -30mV. An AP property that closely correlated with failure of the Ca2+ transient was the integral of AP voltage with respect to ti

SUBMITTER: Wang X 

PROVIDER: S-EPMC8730720 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature