Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics.

ABSTRACT: Antagonistic interactions are widespread in the microbial world and affect microbial evolutionary dynamics. Natural microbial communities often display spatial structure, which affects biological interactions, but much of what we know about microbial antagonism comes from laboratory studies of well-mixed communities. To overcome this limitation, we manipulated two killer strains of the budding yeast Saccharomyces cerevisiae, expressing different toxins, to independently control the rate at which they released their toxins. We developed mathematical models that predict the experimental dynamics of competition between toxin-producing strains in both well-mixed and spatially structured populations. In both situations, we experimentally verified theory's prediction that a stronger antag

SUBMITTER: Giometto A 

PROVIDER: S-EPMC8730724 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature