BOLD asynchrony elucidates tumor burden in IDH-mutated gliomas.

ABSTRACT:

Background

Gliomas comprise the most common type of primary brain tumor, are highly invasive, and often fatal. IDH-mutated gliomas are particularly challenging to image and there is currently no clinically accepted method for identifying the extent of tumor burden in these neoplasms. This uncertainty poses a challenge to clinicians who must balance the need to treat the tumor while sparing healthy brain from iatrogenic damage. The purpose of this study was to investigate the feasibility of using resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to detect glioma-related asynchrony in vascular dynamics for distinguishing tumor from healthy brain.

Methods

Twenty-four stereotactically localized biopsies were obtained during open surgi

SUBMITTER: Petridis PD 

PROVIDER: S-EPMC8730764 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature