Mamma Mia, P-glycoprotein binds again.
Ontology highlight
ABSTRACT:
SUBMITTER: Callaghan R
PROVIDER: S-EPMC8731231 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Mamma Mia, P-glycoprotein binds again.
Callaghan Richard R Gelissen Ingrid C IC George Anthony M AM Hartz Anika M S AMS
FEBS letters 20201020 23
The levels of amyloid peptides in the brain are regulated by a clearance pathway from neurons to the blood-brain barrier. The first step is thought to involve diffusion from the plasma membrane to the interstitium. However, amyloid peptides are hydrophobic and avidly intercalate within membranes. The ABC transporter P-glycoprotein is implicated in the clearance of amyloid peptides across the blood-brain, but its role at neurons is undetermined. We here propose that P-glycoprotein mediates 'exit' ...[more]
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