Dataset Information

SARS-CoV-2 vaccination-associated collapsing glomerulopathy in a kidney transplant recipient.

ABSTRACT:

SUBMITTER: Jefferis J

PROVIDER: S-EPMC8731234 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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SARS-CoV-2 vaccination-associated collapsing glomerulopathy in a kidney transplant recipient.

Jefferis Julia J Kassianos Andrew J AJ Grivei Anca A Doucet Brian B Healy Helen H Francis Leo L Mon Saw Yu SY John George T GT

Kidney international 20220104 3

PMID: 34995649

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Project description:Kidney transplant recipients (KTRs) are still at risk of severe COVID-19 disease after SARS‑CoV‑2 vaccination, especially when they have limited antibody formation. Our aim was to understand the factors that may limit their humoral response.MethodsOur data are derived from KTRs who were enrolled in the Dutch Renal Patients COVID-19 Vaccination consortium, using a discovery cohort and 2 external validation cohorts. Included in the discovery (N = 1804) and first validation (N = 288) cohorts were participants who received 2 doses of the mRNA-1273 vaccine. The second validation cohort consisted of KTRs who subsequently received a third dose of any SARS-CoV-2 vaccine (N = 1401). All participants had no history of SARS-CoV-2 infection. A multivariable logistic prediction model was built using stepwise backward regression analysis with nonseroconversion as the outcome.ResultsThe discovery cohort comprised 836 (46.3%) KTRs, the first validation cohort 124 (43.1%) KTRs, and the second validation cohort 358 (25.6%) KTRs who did not seroconvert. In the final multivariable model' 12 factors remained predictive for nonseroconversion: use of mycophenolate mofetil/mycophenolic acid (MMF/MPA); chronic lung disease, heart failure, and diabetes; increased age; shorter time after transplantation; lower body mass index; lower kidney function; no alcohol consumption; ≥2 transplantations; and no use of mammalian target of rapamycin inhibitors or calcineurin inhibitors. The area under the curve was 0.77 (95% confidence interval [CI], 0.74-0.79) in the discovery cohort after adjustment for optimism, 0.81 (95% CI, 0.76-0.86) in the first validation cohort, and 0.67 (95% CI, 0.64-0.71) in the second validation cohort. The strongest predictor was the use of MMF/MPA, with a dose-dependent unfavorable effect, which remained after 3 vaccinations.ConclusionsIn a large sample of KTRs, we identify a selection of KTRs at high risk of nonseroconversion after SARS-CoV-2 vaccination. Modulation of MMF/MPA treatment before vaccination may help to optimize vaccine response in these KTRs. This model contributes to future considerations on alternative vaccination strategies.

Dataset Information

SARS-CoV-2 vaccination-associated collapsing glomerulopathy in a kidney transplant recipient.

Publications

SARS-CoV-2 vaccination-associated collapsing glomerulopathy in a kidney transplant recipient.

Similar Datasets

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