STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8.

ABSTRACT: Intestinal homeostasis and the maintenance of the intestinal epithelial barrier are essential components of host defense during gastrointestinal Salmonella Typhimurium infection. Both require a strict regulation of cell death. However, the molecular pathways regulating epithelial cell death have not been completely understood. Here, we elucidated the contribution of central mechanisms of regulated cell death and upstream regulatory components during gastrointestinal infection. Mice lacking Caspase-8 in the intestinal epithelium are highly sensitive towards bacterial induced enteritis and intestinal inflammation, resulting in an enhanced lethality of these mice. This phenotype was associated with an increased STAT1 activation during Salmonella infection. Cell death, barrier breakdown and sy

SUBMITTER: Stolzer I 

PROVIDER: S-EPMC8732278 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature