Dataset Information

Exercise Training and Cognitive Function in Kidney Disease: Protocol for a Pilot Randomized Controlled Trial.

ABSTRACT:

Background

Chronic kidney disease (CKD) is extremely common in older adults and is associated with cognitive impairment. It is hypothesized that accelerated cognitive decline in CKD results from a vascular dysfunction-induced reduction in the integrity of the brain white matter.

Objective

The aim of this study was to describe the protocol for a study to evaluate whether exercise training provides a cerebroprotective effect by improving cerebrovascular health.

Methods

This is a randomized controlled trial investigating feasibility and effect size.

Results

Participants will be randomized to either a 24-week, home-based, walking program or a usual care group. Participants will undergo evaluation of cognitive function, brain structure via magnetic reasoning imaging, physical function, physical activity, and vascular function. The primary outcome is change in cognitive function.

Discussion

The findings of this study will help determine whether exercise training influences cognitive function during a therapeutic window in the disease process of cognitive impairment in older adults with CKD.

Conclusion

This protocol describes a study to evaluate cognition and brain structure following a home-based exercise program to an at-risk population.

SUBMITTER: Bronas UG

PROVIDER: S-EPMC8732305 | biostudies-literature | 2022 Jan-Feb 01

REPOSITORIES: biostudies-literature

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Publications

Exercise Training and Cognitive Function in Kidney Disease: Protocol for a Pilot Randomized Controlled Trial.

Bronas Ulf G UG Hannan Mary M Lash James P JP Ajilore Olu O Zhou Xiaohong Joe XJ Lamar Melissa M

Nursing research 20220101 1

<h4>Background</h4>Chronic kidney disease (CKD) is extremely common in older adults and is associated with cognitive impairment. It is hypothesized that accelerated cognitive decline in CKD results from a vascular dysfunction-induced reduction in the integrity of the brain white matter.<h4>Objective</h4>The aim of this study was to describe the protocol for a study to evaluate whether exercise training provides a cerebroprotective effect by improving cerebrovascular health.<h4>Methods</h4>This i ...[more]

PMID: 34570042

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Dataset Information

Exercise Training and Cognitive Function in Kidney Disease: Protocol for a Pilot Randomized Controlled Trial.

Background

Objective

Methods

Results

Discussion

Conclusion

Publications

Exercise Training and Cognitive Function in Kidney Disease: Protocol for a Pilot Randomized Controlled Trial.

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