Alterations in Intestinal Microbiota Composition in Mice Treated With Vitamin D3 or Cathelicidin.

ABSTRACT: Gut microbiota is a complex aggregation of microbial organisms, which offers diverse protective benefits to the host. Dysbiosis of intestinal microbiota is frequently associated with many diseases. Vitamin D3 (VD), which was originally associated with bone health, also possesses antimicrobial activities and can act through antimicrobial peptide. Cathelicidin is a type of antimicrobial peptide in host to maintain the balance of gut microbiome. Our current study sought to evaluate the protective effect of VD and cathelicidin in mice intestines by administration of VD or mCRAMP-encoding L. lactis. We herein provided a comprehensive profile of the impact of VD and mCRAMP on gut microbiota using 16S rRNA sequencing, followed by bioinformatics and statistical analysis. Our results reveale

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8732771 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature