Insulin and the insulin receptor collaborate to promote human gastric cancer.

ABSTRACT:

Background

Gastric adenocarcinoma is common and consequent mortality high. Presentation and mortality are increased in obese individuals, many of whom have elevated circulating insulin concentrations. High plasma insulin concentrations may promote, and increase mortality from, gastric adenocarcinoma. Tumour promotion activities of insulin and its receptor are untested in gastric cancer cells.

Methods

Tumour gene amplification and expression were computed from sequencing and microarray data. Associations with patient survival were assessed. Insulin-dependent signal transduction, growth, apoptosis and anoikis were analysed in metastatic cells from gastric adenocarcinoma patients and in cell lines. Receptor involvement was tested by pharmacological inhibition and genetic knockd

SUBMITTER: Saisana M 

PROVIDER: S-EPMC8732810 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature