Genomic landscape of a mouse model of diffuse-type gastric adenocarcinoma.

ABSTRACT:

Background

There is a need for a model of diffuse-type gastric cancer that captures the features of the disease, facilitates the study of its mechanisms, and aids the development of potential therapies. One such model may be Cdh1 and Trp53 double conditional knockout (DCKO) mice, which have histopathological features similar to those of human diffuse-type gastric cancer. However, a genomic profile of this mouse model has yet to be completed.

Methods

Whole-genome sequences of tumors from eight DCKO mice were analyzed and their molecular features were compared with those of human gastric adenocarcinoma.

Results

DCKO mice gastric cancers harbored single nucleotide variations and indel patterns comparable to those of human genomically stable gastric cancers, whereas their

SUBMITTER: Zhang M 

PROVIDER: S-EPMC8732846 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature