Ontology highlight
ABSTRACT:
SUBMITTER: Asakawa T
PROVIDER: S-EPMC8732922 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Asakawa Takeyoshi T Yamada Atsushi A Kugino Masumi M Hasegawa Tomokazu T Yoshimura Kentaro K Sasa Kiyohito K Kinoshita Mitsuhiro M Nitta Masakazu M Nagata Karin K Sugiyama Tomomi T Kamijo Ryutaro R Funatsu Takahiro T
Human cell 20210929 1
Down's syndrome is one of the most common human congenital genetic diseases and affected patients have increased risk of periodontal disease. To examine involvement of the disease with periodontal disease development, we established immortalized periodontal ligament cells obtained from a Down's syndrome patient by use of SV40T-Ag and hTERT gene transfection. Expressions of SV40T-Ag and hTERT were observed in periodontal ligament cell-derived immortalized cells established from healthy (STPDL) an ...[more]