A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol.

ABSTRACT: The overload cytosolic free Ca²⁺ (cCa²⁺) influx-mediated excessive generation of oxidative stress in the pathophysiological conditions induces neuronal and cellular injury via the activation of cation channels. TRPM2 and TRPV4 channels are activated by oxidative stress, and their specific antagonists have not been discovered yet. The antioxidant and anti-Covid-19 properties of carvacrol (CARV) were recently reported. Hence, I suspected possible antagonist properties of CARV against oxidative stress (OS)/ADP-ribose (ADPR)-induced TRPM2 and GSK1016790A (GSK)-mediated TRPV4 activations in neuronal and kidney cells. I investigated the antagonist role of CARV on the activations of TRPM2 and TRPV4 in SH-SY5Y neuronal, BV-2 microglial, and HEK293 cells. The OS/ADPR and GSK i

SUBMITTER: Nazıroglu M 

PROVIDER: S-EPMC8732973 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature