Linkage disequilibrium under polysomic inheritance.

ABSTRACT: Linkage disequilibrium (LD) is the non-random association of alleles at different loci. Squared LD coefficients r² (for phased genotypes) and [Formula: see text] (for unphased genotypes) will converge to constants that are determined by the sample size, the recombination frequency, the effective population size and the mating system. LD can therefore be used for gene mapping and the estimation of effective population size. However, current methods work only with diploids. To resolve this problem, we here extend the linkage disequilibrium measures to include polysomic inheritance. We derive the values of r² and [Formula: see text] at equilibrium state for various mating systems and different ploidy levels. For unlinked loci, [Formula: see text] for monoecious and dioec

SUBMITTER: Huang K 

PROVIDER: S-EPMC8733019 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature