Temporal and genomic analysis of additive genetic variance in breeding programmes.

ABSTRACT: Genetic variance is a central parameter in quantitative genetics and breeding. Assessing changes in genetic variance over time as well as the genome is therefore of high interest. Here, we extend a previously proposed framework for temporal analysis of genetic variance using the pedigree-based model, to a new framework for temporal and genomic analysis of genetic variance using marker-based models. To this end, we describe the theory of partitioning genetic variance into genic variance and within-chromosome and between-chromosome linkage-disequilibrium, and how to estimate these variance components from a marker-based model fitted to observed phenotype and marker data. The new framework involves three steps: (i) fitting a marker-based model to data, (ii) sampling realisations of marker eff

SUBMITTER: Lara LAC 

PROVIDER: S-EPMC8733024 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature