The Impact of Space and Time on the Functional Output of the Genome.
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ABSTRACT:
SUBMITTER: Nollmann M
PROVIDER: S-EPMC8733053 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
The Impact of Space and Time on the Functional Output of the Genome.
Nollmann Marcelo M Bennabi Isma I Götz Markus M Gregor Thomas T
Cold Spring Harbor perspectives in biology 20220517 4
Over the past two decades, it has become clear that the multiscale spatial and temporal organization of the genome has important implications for nuclear function. This review centers on insights gained from recent advances in light microscopy on our understanding of transcription. We discuss spatial and temporal aspects that shape nuclear order and their consequences on regulatory components, focusing on genomic scales most relevant to function. The emerging picture is that spatiotemporal const ...[more]
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