Association of a SNP in the IAPP gene and hyperglycemia on β-cell dysfunction in type 2 diabetes: the Toon Genome Study.

ABSTRACT:

Objective

In type 2 diabetes, the significant pathological change in pancreatic islets is amyloid deposits. Its major component is islet amyloid polypeptide (IAPP). The objective of this study was to evaluate the possibility that the effect of the IAPP genotype on β-cell dysfunction in type 2 diabetes is modified by variations in plasma glucose levels.

Methods

Participants from the Toon Genome Study underwent a 75 g OGTT for the diagnosis of glucose tolerance and the evaluation of insulin secretion. We examined the effect of a SNP, rs77397980, on β-cell function by analyzing an interaction (statistics) between the IAPP genotype and AUC glucose.

Results

The ratio of the C-allele carriers was essentially the same among subjects with normal glucose toleranc

SUBMITTER: Kawamura R 

PROVIDER: S-EPMC8733094 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature