Mapping an Extended Metabolic Profile of Gliomas Using High-Resolution ³¹P MRSI at 7T.

ABSTRACT: Phosphorus magnetic resonance spectroscopic imaging (³¹P MRSI) is of particular interest for investigations of patients with brain tumors as it enables to non-invasively assess altered energy and phospholipid metabolism in vivo. However, the limited sensitivity of ³¹P MRSI hampers its broader application at clinical field strengths. This study aimed to identify the additional value of ³¹P MRSI in patients with glioma at ultra-high B ₀ = 7T, where the increase in signal-to-noise ratio may foster its applicability for clinical research. High-quality, 3D ³¹P MRSI datasets with an effective voxel size of 5.7 ml were acquired from the brains of seven patients with newly diagnosed glioma. An optimized quantification model was i

SUBMITTER: Korzowski A 

PROVIDER: S-EPMC8733158 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature