Urinary Soluble CD163 Levels Predict IgA Nephropathy Remission Status.

ABSTRACT: Noninvasive biomarkers of disease activity are needed to predict disease remission status in patients with IgA nephropathy (IgAN). Soluble CD163 (sCD163), shed by monocytes and macrophages, is a potential biomarker in diseases associated with excessive macrophage activation. We investigated the association of urinary sCD163 (u-sCD163) with histopathological activity and clinical manifestations in 349 patients with biopsy-diagnosed IgAN. U-sCD163 was measured via enzyme-linked immunosorbent assay. In patients with IgAN, higher u-sCD163 levels were associated with histological lesions of greater severity, as well as more proteinuria and poorer renal function. Additionally, u-sCD163 was correlated with infiltration of tubulointerstitial CD163⁺ macrophages. High u-sCD163 leve

SUBMITTER: Gong S 

PROVIDER: S-EPMC8733336 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature