The distribution of mutational effects on fitness in Caenorhabditis elegans inferred from standing genetic variation.

ABSTRACT: The distribution of fitness effects (DFE) for new mutations is one of the most theoretically important but difficult to estimate properties in population genetics. A crucial challenge to inferring the DFE from natural genetic variation is the sensitivity of the site frequency spectrum to factors like population size change, population substructure, genome structure, and nonrandom mating. Although inference methods aim to control for population size changes, the influence of nonrandom mating remains incompletely understood, despite being a common feature of many species. We report the DFE estimated from 326 genomes of Caenorhabditis elegans, a nematode roundworm with a high rate of self-fertilization. We evaluate the robustness of DFE inferences using simulated data that mimics the genomic

SUBMITTER: Gilbert KJ 

PROVIDER: S-EPMC8733438 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature