Insulin signaling and osmotic stress response regulate arousal and developmental progression of C. elegans at hatching.

ABSTRACT: The progression of animal development from embryonic to juvenile life depends on the coordination of organism-wide responses with environmental conditions. We found that two transcription factors that function in interneuron differentiation in Caenorhabditis elegans, fax-1, and unc-42, are required for arousal and progression from embryogenesis to larval life by potentiating insulin signaling. The combination of mutations in either transcription factor and a mutation in daf-2 insulin receptor results in a novel perihatching arrest phenotype; embryos are fully developed but inactive, often remaining trapped within the eggshell, and fail to initiate pharyngeal pumping. This pathway is opposed by an osmotic sensory response pathway that promotes developmental arrest and a sleep state at the e

SUBMITTER: Bayer EA 

PROVIDER: S-EPMC8733457 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature