Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice.

ABSTRACT: Dietary interventions can dramatically affect physiological health and organismal lifespan. The degree to which organismal health is improved depends upon genotype and the severity of dietary intervention, but neither the effects of these factors, nor their interaction, have been quantified in an outbred population. Moreover, it is not well understood what physiological changes occur shortly after dietary change and how these may affect the health of an adult population. In this article, we investigated the effect of 6-month exposure of either caloric restriction (CR) or intermittent fasting (IF) on a broad range of physiological traits in 960 1-year old Diversity Outbred mice. We found CR and IF affected distinct aspects of physiology and neither the magnitude nor the direction (beneficia

SUBMITTER: Zhang G 

PROVIDER: S-EPMC8733459 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature