The Relationship Between Gut Microbiome Features and Chemotherapy Response in Gastrointestinal Cancer.

ABSTRACT:

Objective

The prognosis of advanced gastrointestinal cancer is poor. There are studies indicating that gut microbes might have the predictive ability to evaluate the outcome of cancer therapy, especially immunotherapy. There is limited evidence to date on the influence of microbes on chemotherapeutic response.

Design

In total, 130 patients with advanced or metastatic esophageal (n=40), gastric (n=46), and colorectal cancer (n=44) were enrolled. We included 147 healthy people as controls and used 16S rRNA sequencing to analyze the fecal microbiota.

Results

Significant differences in the abundance of fecal microbiota between patients with gastrointestinal cancer and controls were identified. The abundance of Bacteroides fragilis, Escherichia coli, Akker

SUBMITTER: Li N 

PROVIDER: S-EPMC8733568 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature