β-Tubulin Isotype, TUBB4B, Regulates The Maintenance of Cancer Stem Cells.

ABSTRACT: Recent advancements in cancer research have shown that cancer stem cell (CSC) niche is a crucial factor modulating tumor progression and treatment outcomes. It sustains CSCs by orchestrated regulation of several cytokines, growth factors, and signaling pathways. Although the features defining adult stem cell niches are well-explored, the CSC niche is poorly characterized. Since membrane trafficking proteins have been shown to be essential for the localization of critical proteins supporting CSCs, we investigated the role of TUBB4B, a probable membrane trafficking protein that was found to be overexpressed in the membranes of stem cell enriched cultures, in sustaining CSCs in oral cancer. Here, we show that the knockdown of TUBB4B downregulates the expression of pluripotency markers, deplet

SUBMITTER: Dharmapal D 

PROVIDER: S-EPMC8733585 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature