Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma.

ABSTRACT:

Background

Accumulating studies have demonstrated the abnormal expressions and prognostic values of certain members of the tripartite motif (TRIM) family in diverse cancers. However, comprehensive prognostic values of the TRIM family in hepatocellular carcinoma (HCC) are yet to be clearly defined.

Methods

The prognostic values of the TRIM family were evaluated by survival analysis and univariate Cox regression analysis based on gene expression data and clinical data of HCC from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The expression profiles, protein-protein interaction among the TRIM family, prediction of transcription factors (TFs) or miRNAs, genetic alterations, correlations with the hallmarks of cancer and immune infiltrates, and pathwa

SUBMITTER: Dai W 

PROVIDER: S-EPMC8733586 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature