Comprehensive Analyses of the Expression, Genetic Alteration, Prognosis Significance, and Interaction Networks of m⁶A Regulators Across Human Cancers.

ABSTRACT: Accumulating lines of evidence indicate that the deregulation of m⁶A is involved in various cancer types. The m⁶A RNA methylation is modulated by m⁶A methyltransferases, demethylases, and reader proteins. Although the aberrant expression of m⁶A RNA methylation contributes to the development and progression of multiple cancer types, the roles of m⁶A regulators across numerous types of cancers remain largely unknown. Here, we comprehensively investigated the expression, genetic alteration, and prognosis significance of 20 commonly studied m⁶A regulators across diverse cancer types using TCGA datasets via bioinformatic analyses. The results revealed that the m⁶A regulators exhibited widespread dysregulation, g

SUBMITTER: Shi X 

PROVIDER: S-EPMC8733627 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature