Lipids and Phosphorylation Conjointly Modulate Complex Formation of β₂-Adrenergic Receptor and β-arrestin2.

ABSTRACT: G protein-coupled receptors (GPCRs) are the largest class of human membrane proteins that bind extracellular ligands at their orthosteric binding pocket to transmit signals to the cell interior. Ligand binding evokes conformational changes in GPCRs that trigger the binding of intracellular interaction partners (G proteins, G protein kinases, and arrestins), which initiate diverse cellular responses. It has become increasingly evident that the preference of a GPCR for a certain intracellular interaction partner is modulated by a diverse range of factors, e.g., ligands or lipids embedding the transmembrane receptor. Here, by means of molecular dynamics simulations of the β₂-adrenergic receptor and β-arrestin2, we study how membrane lipids and receptor phosphorylation regulate GPCR

SUBMITTER: Pluhackova K 

PROVIDER: S-EPMC8733679 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature