Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome.

ABSTRACT:

Background

Paternal lifestyle choices and male exposure history have a critical influence on the health and fitness of the next generation. Accordingly, defining the processes of germline programming is essential to resolving how the epigenetic memory of paternal experiences transmits to their offspring. Established dogma holds that all facets of chromatin organization and histone posttranslational modification are complete before sperm exits the testes. However, recent clinical and animal studies suggest that patterns of DNA methylation change during epididymal maturation. In this study, we used complementary proteomic and deep-sequencing approaches to test the hypothesis that sperm posttranslational histone modifications change during epididymal transit.

Results

Using prot

SUBMITTER: Bedi YS 

PROVIDER: S-EPMC8734183 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature