Non-parametric synergy modeling of chemical compounds with Gaussian processes.

ABSTRACT:

Background

Understanding the synergetic and antagonistic effects of combinations of drugs and toxins is vital for many applications, including treatment of multifactorial diseases and ecotoxicological monitoring. Synergy is usually assessed by comparing the response of drug combinations to a predicted non-interactive response from reference (null) models. Possible choices of null models are Loewe additivity, Bliss independence and the recently rediscovered Hand model. A different approach is taken by the MuSyC model, which directly fits a generalization of the Hill model to the data. All of these models, however, fit the dose-response relationship with a parametric model.

Results

We propose the Hand-GP model, a non-parametric model based on the combination of the Hand model

SUBMITTER: Shapovalova Y 

PROVIDER: S-EPMC8734200 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature