SweepCluster: A SNP clustering tool for detecting gene-specific sweeps in prokaryotes.

ABSTRACT:

Background

The gene-specific sweep is a selection process where an advantageous mutation along with the nearby neutral sites in a gene region increases the frequency in the population. It has been demonstrated to play important roles in ecological differentiation or phenotypic divergence in microbial populations. Therefore, identifying gene-specific sweeps in microorganisms will not only provide insights into the evolutionary mechanisms, but also unravel potential genetic markers associated with biological phenotypes. However, current methods were mainly developed for detecting selective sweeps in eukaryotic data of sparse genotypes and are not readily applicable to prokaryotic data. Furthermore, some challenges have not been sufficiently addressed by the methods, such as the low s

SUBMITTER: Qiu J 

PROVIDER: S-EPMC8734265 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature