Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines.

ABSTRACT:

Background

The United Kingdom guideline for acute paracetamol overdose has recommended the use of '100-treatment line'. Emergency medical centers in some developing countries lack the resources for timely reporting of paracetamol concentrations, hence treatment depends on reported dose. This study aimed to examine whether using an reported dose is safe to predict concentration above the 100-line.

Methods

Data were retrieved from two emergency medical centers retrospectively, between 2010 and 2017. The inclusion criteria were single acute paracetamol overdose, presentation within 15 h, and age ≥ 14 years. Multiple linear regression was performed to determine the effect of ingested dose on paracetamol concentration. Subgroups were created based on ingested dose, rate of concen

SUBMITTER: Jeong HH 

PROVIDER: S-EPMC8734297 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature