An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development.

ABSTRACT:

Background

Genetic polymorphisms play a crucial role in the development of osteonecrosis of the femoral head (ONFH). This study mainly explored the association of IL-6 variants and ONFH susceptibility among the Chinese Han population.

Methods

Two variants (rs2069837, and rs13306435) in the IL-6 gene were identified and genotyped from 566 patients with ONFH and 566 healthy controls. The associations between IL-6 polymorphisms and ONFH susceptibility were assessed using odds ratio (OR) and 95% confidence interval (95% CI) via logistic regression. The potential function of these two variants was predicted by the HaploReg online database.

Results

The results of the overall analysis revealed that IL-6 rs2069837 was correlated with decreased risk of ONFH among the Chinese H

SUBMITTER: Wang R 

PROVIDER: S-EPMC8734317 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature