Protein complexes detection based on node local properties and gene expression in PPI weighted networks.

ABSTRACT:

Background

Identifying protein complexes from protein-protein interaction (PPI) networks is a crucial task, and many related algorithms have been developed. Most algorithms usually employ direct neighbors of nodes and ignore resource allocation and second-order neighbors. The effective use of such information is crucial to protein complex detection.

Result

Based on this observation, we propose a new way by combining node resource allocation and gene expression information to weight protein network (NRAGE-WPN), in which protein complexes are detected based on core-attachment and second-order neighbors.

Conclusions

Through comparison with eleven methods in Yeast and Human PPI network, the experimental results demonstrate that this algorithm not only performs better than

SUBMITTER: Yu Y 

PROVIDER: S-EPMC8734347 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature