Preeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case control study.

ABSTRACT:

Background

Preeclampsia is characterized by decreased trophoblastic angiogenesis leading to abnormal invasion of spiral arteries, shallow implantation and resulting in compromised placentation with poor uteroplacental perfusion. Vitamin D plays an important role in pregnancy influencing implantation, angiogenesis and placental development. The objective of this study was to determine whether there is an association between serum vitamin D levels, and anti-angiogenic factors at the time of delivery and the occurrence of preeclampsia.

Methods

This nested case control study analyzed frozen serum samples at the time of delivery and related clinical data from women with singleton liveborn pregnancies who had participated in studies of the NICHD Stillbirth Collaborative Research N

SUBMITTER: Seifer DB 

PROVIDER: S-EPMC8734360 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature