Helicobacter pylori associated aberrant methylation genes in blood leukocyte and gastric mucosa.

ABSTRACT: Background and Aim: Methylation alterations may be involved in Helicobacter pylori-associated gastric carcinogenesis. This study aims to explore the potential H.pylori-associated methylation biomarkers in blood leukocyte and gastric mucosa. Methods: Five candidate H.pylori-associated aberrant methylation genes were selected from the previous genome-wide profiling panels and validated in blood leukocyte and gastric mucosa in multi-stages (case-control validation between H.pylori positive and negative subjects and self-control validation before and after anti-H.pylori treatment). Results: GNAS methylation level was decreased in blood leukocyte (62.07% v.s. 46.33%, p<0.001) and gastric mucosa (56.30% v.s. 32.4

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8734399 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature