Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease.

ABSTRACT: Networks are present in many aspects of our lives, and networks in neuroscience have recently gained much attention leading to novel representations of brain connectivity. The integration of neuroimaging characteristics and genetics data allows a better understanding of the effects of the gene expression on brain structural and functional connections. The current work uses whole-brain tractography in a longitudinal setting, and by measuring the brain structural connectivity changes studies the neurodegeneration of Alzheimer's disease. This is accomplished by examining the effect of targeted genetic risk factors on the most common local and global brain connectivity measures. Furthermore, we examined the extent to which Clinical Dementia Rating relates to brain connections longitudinally, a

SUBMITTER: Elsheikh SSM 

PROVIDER: S-EPMC8734427 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature