Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey.

ABSTRACT:

Background

Polychlorinated biphenyl (PCB) exposures have been associated with liver injury in human cohorts, and steatohepatitis with liver necrosis in model systems. MicroRNAs (miRs) maintain cellular homeostasis and may regulate the response to environmental stress.

Objectives

We tested the hypothesis that specific miRs are associated with liver disease and PCB exposures in a residential cohort.

Methods

Sixty-eight targeted hepatotoxicity miRs were measured in archived serum from 734 PCB-exposed participants in the cross-sectional Anniston Community Health Survey. Necrotic and other liver disease categories were defined by serum keratin 18 (K18) biomarkers. Associations were determined between exposure biomarkers (35 ortho-substituted PCB congeners) and disease biom

SUBMITTER: Cave MC 

PROVIDER: S-EPMC8734566 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature