Sex Differences in Orthostatic Tolerance Are Mainly Explained by Blood Volume and Oxygen Carrying Capacity.

ABSTRACT:

Objectives

The reduced orthostatic tolerance (OT) that is characteristic of the female sex may be explained by multiple phenotypic differences between sexes. This study aimed to elucidate the mechanistic role of blood volume (BV) and oxygen carrying capacity on sex differences in OT.

Design

Experimental intervention.

Setting

University of Calgary, Main Campus, Calgary, AB, Canada.

Subjects

Healthy women and men (n = 90) throughout the adult lifespan (20-89 yr) matched by age and physical activity.

Interventions

Incremental lower body negative pressure (LBNP) in all individuals. Blood withdrawal and oxygen carrying capacity reduction in men to match with women's levels.

Measurements and main results

Transthoracic echocardiography and central

SUBMITTER: Diaz-Canestro C 

PROVIDER: S-EPMC8735745 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature