A Prospective Observational Study Comparing Clinical Sepsis Criteria to Protein Biomarkers Reveals a Role for Vascular Dysfunction in Burn Sepsis.

ABSTRACT:

Objectives

To compare the diagnostic value of clinical sepsis criteria to novel protein biomarkers in the burn patient.

Design

Prospective observational study.

Setting

American Burn Association verified Burn Center ICU.

Patients

Burn patients (n = 24) and healthy volunteers (n = 10).

Interventions

Enrolled burn patients (n = 24) were stratified based on whether or not they met a clinical definition of sepsis. Four separate clinical criteria for sepsis were analyzed for their diagnostic sensitivity and specificity, which were compared to a panel of protein biomarkers. The most significant protein biomarkers were further analyzed via the area under the receiver operating characteristic curves (AUROCs).

Measurements and main results<

SUBMITTER: Burmeister DM 

PROVIDER: S-EPMC8735811 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature