Effect of Sodium-Glucose Cotransporter 2 Inhibitors on Weight Reduction in Overweight and Obese Populations without Diabetes: A Systematic Review and a Meta-Analysis.

ABSTRACT:

Background

We aimed to evaluate the efficacy of sodium-glucose cotransporter 2 (SGLT2) inhibitors for managing obesity in non-diabetic overweight or obese patients.

Methods

For purposes of this study, PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials were searched through May 2021. Randomized controlled trials published in English that compared SGLT2 inhibitors with placebo in overweight and obese patients without diabetes were included in the primary analysis. The random effects standardized mean difference ±95% confidence interval (95% CI) was calculated as the effect size.

Results

Five randomized controlled trials were included to evaluate body weight change, four trials to assess body mass index (BMI), and three trials to asses

SUBMITTER: Cho YK 

PROVIDER: S-EPMC8735829 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature