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ABSTRACT:
SUBMITTER: Jakimiuk K
PROVIDER: S-EPMC8735877 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Jakimiuk Katarzyna K Sari Suat S Milewski Robert R Supuran Claudiu T CT Şöhretoğlu Didem D Tomczyk Michał M
Journal of enzyme inhibition and medicinal chemistry 20221201 1
Flavonoids are widely distributed in plants and constitute the most common polyphenolic phytoconstituents in the human diet. In this study, the <i>in vitro</i> inhibitory activity of 44 different flavonoids (<b>1-44</b>) against mushroom tyrosinase was studied, and an <i>in silico</i> study and type of inhibition for the most active compounds were evaluated too. Tyrosinase inhibitors block melanogenesis and take part in melanin production or distribution leading to pigmentation diseases. The <i> ...[more]