Subsequent malignant neoplasms in the Childhood Cancer Survivor Study: Occurrence of cancer types in which human papillomavirus is an established etiologic risk factor.

ABSTRACT:

Background

Human papillomavirus (HPV)-associated subsequent malignant neoplasms (SMN_HPV ) in childhood cancer survivors are poorly understood.

Methods

The cumulative risk of SMN_HPV was assessed among 24,363 Childhood Cancer Survivor Study participants. Standardized incidence ratios (SIRs) and absolute excess risk were calculated using age-matched, sex-matched, and calendar year rates from the Surveillance, Epidemiology, and End Results program. Poisson regression models identified SMN_HPV risk factors, evaluating relative SIRs (rSIR) and 95% confidence intervals (95% CIs).

Results

In total, 46 survivors developed an SMN_HPV (median age, 31 years [range, 10-56 years]; median time from primary cancer, 21 years [range, 9-35 years

SUBMITTER: Henderson TO 

PROVIDER: S-EPMC8738100 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature